Pregnant women are vulnerable to iodine deficiency, which poses risks to maternal and fetal health. Preventive education on iodine intake is essential to reduce these risks. This quasi-experimental study evaluated the effectiveness of innovative interactive education techniques on pregnant women’s knowledge, attitudes, and practices (KAP) regarding iodine deficiency. A total of 132 pregnant women attending Suez Canal University Hospital clinics were divided into an intervention group, which received interactive education, and a control group, which received standard education. The intervention included multimedia presentations, group discussions, and digital tools focused on the importance of iodine. Results indicated significant improvements in knowledge, attitudes, and dietary practices related to iodine intake in the intervention group, with sustained effects at follow-up. These findings highlight the potential of interactive education in promoting preventive health behaviors among pregnant women.